Chawla A, Schwarz E J, Dimaculangan D D, Lazar M A
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104.
Endocrinology. 1994 Aug;135(2):798-800. doi: 10.1210/endo.135.2.8033830.
Activators of peroxisome proliferator activated receptor (PPAR) regulate fatty acid metabolism and can induce adipocyte differentiation. We show here that the gamma subtype of PPAR is expressed at high levels in adipose tissue in contrast to a variety of other tissues, where little gene expression was noted. In addition, PPAR gamma is present at low levels in 3T3-L1 preadipocytes and is induced dramatically during adipocyte conversion using either normal differentiating conditions (fetal calf serum, dexamethasone, isobutyl-methylxanthine, and insulin) or the PPAR activator, WY-14,643. Thus PPAR gamma may be important for adipose cell development and function.
过氧化物酶体增殖物激活受体（PPAR）的激活剂可调节脂肪酸代谢，并能诱导脂肪细胞分化。我们在此表明，与多种其他组织相比，PPAR的γ亚型在脂肪组织中高水平表达，而在这些其他组织中几乎没有基因表达。此外，PPARγ在3T3-L1前脂肪细胞中低水平存在，并且在使用正常分化条件（胎牛血清、地塞米松、异丁基甲基黄嘌呤和胰岛素）或PPAR激活剂WY-14,643进行脂肪细胞转化过程中会显著诱导表达。因此，PPARγ可能对脂肪细胞的发育和功能很重要。
