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[免疫检测在子宫绒毛膜上皮癌与葡萄胎鉴别诊断中的应用]

[Use of an immunologic test for differential diagnosis of uterine chorionepithelioma and hydatid mole].

作者信息

Savinskaia A P, Novikova L A

出版信息

Biull Eksp Biol Med. 1975 Jan;79(1):60-3.

PMID:803384
Abstract

Polysaccharide complexes obtained by Westphal's method (modified by L. A. Zilbert et al) from the tissue of a primary tumour node and remote metastases (the lungs) of chorionoepithelioma of the uterus were used for differential diagnosis of chorionepithelioma of the uterus and hydatid mole. Investigations carried out showed that the reaction to the intradermal injection of polysaccharide complexes obtained from the remote metastases (the lungs) of chorionepithelioma of the uterus was highly specific and sensitive: positive reaction occurred only in the patients with chorionepithelioma of the uterus, and it was negative in the patients with hydatid mole. With a marked diminution (in the course of chemotherapy) of metastases in the lungs, when the immunological reaction to chorionic gonadotropin fell to 300--100 IU per litre of the urine, reaction to the intradermal injection of polysaccharide complexes from the metastases of chorionepithelioma of the uterus still remained positive.

摘要

采用由L. A. 齐尔伯特等人改良的韦斯特法尔法,从子宫绒毛膜上皮癌原发肿瘤结节及远处转移灶(肺)组织中获得的多糖复合物,用于子宫绒毛膜上皮癌与葡萄胎的鉴别诊断。所开展的研究表明,对子宫绒毛膜上皮癌远处转移灶(肺)获得的多糖复合物进行皮内注射的反应具有高度特异性和敏感性:仅子宫绒毛膜上皮癌患者出现阳性反应,而葡萄胎患者为阴性反应。在肺部转移灶(化疗过程中)显著减少时,当对绒毛膜促性腺激素的免疫反应降至每升尿液300 - 100国际单位时,对子宫绒毛膜上皮癌转移灶多糖复合物进行皮内注射的反应仍为阳性。

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