Brown M L, Hung J C, Vetter R J, O'Connor M K, Chowdhury S, Forstrom L A
Department of Diagnostic Radiology, Mayo Clinic and Foundation, Rochester, Minnesota.
Invest Radiol. 1994 Apr;29(4):443-7. doi: 10.1097/00004424-199404000-00010.
Indium-111 (111In)-labeled leukocyte scanning has been used frequently in patients suspected of having infections. Recently, technetium-99m hexamethylpropylene amine oxime (99mTc-HMPAO) has been used to label leukocytes. This study was undertaken to determine the distribution and dosimetry of 99mTc-HMPAO leukocytes in healthy subjects.
Five healthy volunteers had leukocytes labeled with 99mTc-HMPAO. After injection of the labeled leukocytes, whole body images and blood and urine samples were obtained at multiple time points.
Visual interpretation of the images demonstrated significant bowel activity as early as 2 hours and increasing with time such that one the 8- and 24-hour images, the amount of bowel activity would preclude using 99mTc-HMPAO leukocyte scanning for abdominal processes. The dosimetry for this study is similar to that of other studies and is in an acceptable diagnostic range.
99mTc-HMPAO leukocyte studies are an acceptable alternative to 111In-labeled leukocyte studies in terms of dosimetry. Use of such studies in the abdomen should be limited to early images, usually before 2 hours, to avoid confusion with the normal route of excretion in the bowel.
铟 - 111（¹¹¹In）标记的白细胞扫描已常用于疑似感染的患者。最近，锝 - 99m六甲基丙烯胺肟（⁹⁹ᵐTc - HMPAO）已被用于标记白细胞。本研究旨在确定健康受试者中⁹⁹ᵐTc - HMPAO标记白细胞的分布及剂量学情况。
5名健康志愿者的白细胞用⁹⁹ᵐTc - HMPAO进行标记。注射标记白细胞后，在多个时间点获取全身图像以及血液和尿液样本。
图像的视觉解读显示，早在2小时就有明显的肠道活性，且随时间增加，以至于在8小时和24小时图像上，肠道活性会妨碍使用⁹⁹ᵐTc - HMPAO白细胞扫描来评估腹部病变。本研究的剂量学情况与其他研究相似，且处于可接受的诊断范围内。
在剂量学方面，⁹⁹ᵐTc - HMPAO白细胞研究是¹¹¹In标记白细胞研究的可接受替代方法。此类研究在腹部的应用应限于早期图像，通常在2小时之前，以避免与肠道正常排泄途径混淆。
