Burns M K, Chen S P, Goldberg L H
Baylor College of Medicine, Houston, Texas.
J Dermatol Surg Oncol. 1994 Jul;20(7):429-34. doi: 10.1111/j.1524-4725.1994.tb03212.x.
Microcystic adnexal carcinoma is a slow-growing, nondescript, locally aggressive, deeply infiltrating neoplasm histologically characterized by an infiltrative pattern of basaloid or squamous cells, a desmoplastic stromal reaction, keratin-filled cysts, and glandular structures.
Microcystic adnexal carcinoma is uncommon and may be mistaken microscopically for other benign and malignant entities. Perineural or intraneural involvement by tumor cells is characteristic and extension into underlying structures including muscle, fat, and bone are frequently encountered. Although local recurrences are common after standard surgical excision, metastases have not been reported. Extensive resections of lesions may be necessary to extirpate widespread tumor, particularly those that are long standing or recurrent. Because significantly increased morbidity is associated with recurrent disease, surgical and histopathologic techniques that stress examination of all margins are advantageous.
We review the course of 10 patients with microcystic adnexal carcinoma of the face (six primary and four recurrent lesions) and their treatment by Mohs micrographic surgery.
微囊性附属器癌是一种生长缓慢、外观不明显、局部侵袭性强、深部浸润性肿瘤，其组织学特征为基底样或鳞状细胞呈浸润性生长模式、促纤维增生性间质反应、充满角蛋白的囊肿以及腺管结构。
微囊性附属器癌较为罕见，在显微镜下可能被误诊为其他良性和恶性病变。肿瘤细胞侵犯神经或神经内浸润是其特征，且常累及深部结构，包括肌肉、脂肪和骨骼。尽管标准手术切除后局部复发很常见，但尚未有转移的报道。对于广泛的肿瘤，尤其是长期存在或复发的肿瘤，可能需要进行广泛切除以彻底清除病变。由于复发性疾病会显著增加发病率，强调对所有切缘进行检查的手术和组织病理学技术具有优势。
我们回顾了10例面部微囊性附属器癌患者（6例原发性病变和4例复发性病变）的病程以及他们接受莫氏显微外科手术的治疗情况。
