儿童急性淋巴细胞白血病中的抗铜绿假单胞菌热稳定调理素

Anti-Pseudomonas heat-stable opsonins in acute lymphoblastic leukemia of childhood.

作者信息

Wollman M R, Young L S, Armstrong D, Haghbin M

出版信息

J Pediatr. 1975 Mar;86(3):376-81. doi: 10.1016/s0022-3476(75)80966-8.

Abstract

Heat-stable opsonic activity against Pseudomonas aeruginosa and Staphylococcus epidermidis was measured in sera of 33 children with acute lymphoblastic leukemia at selected times during treatment of their disease. Compared to adults, opsonization of P. aeruginosa was normal in children tested at the time of diagnosis and before chemotherapy. Immediately after achievement of remission, opsonic activity against Pseudomonas was significantly decreased (P smaller than 0.05) compared with pretreatment activity. Activity usually returned to normal and remained so during long-term remission maintenance therapy. In children studied just prior to death from unremitting leukemia, however, anti-Pseudomonas opsonic activity was significantly decreased when compared with that of a group of children before any leukemic treatment (p smaller than 0.005). Anti-S. EPIDERMIDIS OPSONIC ACTIVITY SHOWED NO CHANGES DURING THE PATIENT'S COURSE. Decreased serum opsonic activity may significantly contribute to the increased incidence of severe Pseudomonas infections in patients with acute lymphoblastic leukemia.

摘要

在33名急性淋巴细胞白血病患儿疾病治疗的特定时间点，测定了其血清中针对铜绿假单胞菌和表皮葡萄球菌的热稳定调理活性。与成人相比，在诊断时和化疗前检测的儿童中，铜绿假单胞菌的调理作用正常。在达到缓解后立即检测发现，与预处理活性相比，针对铜绿假单胞菌的调理活性显著降低（P小于0.05）。在长期缓解维持治疗期间，活性通常恢复正常并保持如此。然而，在死于难治性白血病之前接受研究的儿童中，与一组未接受任何白血病治疗的儿童相比，抗铜绿假单胞菌调理活性显著降低（P小于0.005）。抗表皮葡萄球菌调理活性在患者病程中未显示变化。血清调理活性降低可能是急性淋巴细胞白血病患者严重铜绿假单胞菌感染发生率增加的重要原因。