Groenink L, van der Gugten J, Mos J, Maes R A, Olivier B
Department of Psychopharmacology, Faculty of Pharmacy, Utrecht University, The Netherlands.
Life Sci. 1994;55(5):PL99-103. doi: 10.1016/0024-3205(94)00654-7.
The putative silent 5-HT1A receptor antagonist (S)-UH301 (S-5-fluoro-8-hydroxy-2-(di-n-propylamino)tetralin) dose-dependently enhanced (3 to 10 mg/kg, sc) plasma corticosterone levels in undisturbed rats, an effect shared with 5-HT1A receptor agonists. (S)-UH301 did not influence plasma glucose levels. This unexpected finding may be indicative of a partial 5-HT1A-receptor agonistic effect of (S)-UH301, or reveals a hitherto unknown mechanism of action in (S)-UH301.
假定的5-羟色胺1A受体沉默拮抗剂（S）-UH301（S-5-氟-8-羟基-2-（二正丙基氨基）四氢化萘）能剂量依赖性地提高（皮下注射3至10毫克/千克）未受干扰大鼠的血浆皮质酮水平，这一效应与5-羟色胺1A受体激动剂相同。（S）-UH301不影响血浆葡萄糖水平。这一意外发现可能表明（S）-UH301具有部分5-羟色胺1A受体激动作用，或者揭示了（S）-UH301一种迄今未知的作用机制。
