Snyder S W, Rigby S L, Adams H R
E102 College of Veterinary Medicine, University of Missouri, Columbia 65211.
Life Sci. 1994;55(5):399-411. doi: 10.1016/0024-3205(94)00651-2.
This study tested the hypothesis that the decidua of pregnant uterus modulates contractile behavior of the underlying myometrium. Isometric contractile function was measured in transverse rings of pregnant rat uterus with or without the decidua. Observations were made of spontaneous contractions after in vitro isolation, and also of contractile responses to oxytocin and prostaglandin F2 alpha (PGF2 alpha) after the tissues had ceased spontaneous mechanical activity. The amplitude and frequency of spontaneous uterine contractions progressively declined after in vitro isolation; during this period, amplitude of spontaneous contractions was greater in the presence of the decidua, whereas contraction frequency was similar in the decidua-intact and decidua-removed tissues. Reinsertion of donor decidua reproduced contractile characteristics of intact tissue. PGF2 alpha and oxytocin stimulated myometrial contractions, but contraction frequency was greater in the absence than in the presence of the decidua. Depending upon the stimulus, the decidua seems able to express both excitatory and inhibitory factors which can selectively modulate either strength or frequency of uterine contractions.
妊娠子宫的蜕膜调节其下方子宫肌层的收缩行为。在有或没有蜕膜的妊娠大鼠子宫横向环中测量等长收缩功能。观察体外分离后的自发收缩，以及组织停止自发机械活动后对催产素和前列腺素F2α（PGF2α）的收缩反应。体外分离后，子宫自发收缩的幅度和频率逐渐下降；在此期间，有蜕膜时自发收缩的幅度更大，而有蜕膜和去除蜕膜的组织中收缩频率相似。重新植入供体蜕膜可重现完整组织的收缩特征。PGF2α和催产素刺激子宫肌层收缩，但在没有蜕膜时收缩频率更高。根据刺激因素不同，蜕膜似乎能够表达兴奋性和抑制性因子，这些因子可选择性地调节子宫收缩的强度或频率。
