McLachlan S A, Millward M J, Toner G C, Guiney M J, Bishop J F
Peter MacCallum Cancer Institute, Melbourne, Vic.
Med J Aust. 1994 Aug 1;161(3):207-9. doi: 10.5694/j.1326-5377.1994.tb127384.x.
To report three cases of cardiotoxicity related to the administration of 5-fluorouracil (5-FU) in patients with cancer.
Three patients with gastrointestinal malignancies were being treated with combined radiotherapy and chemotherapy regimens. Two patients developed myocardial ischaemia and the other a ventricular arrhythmia in association with 5-FU administration.
All patients survived the cardiac event. No patient was rechallenged with 5-FU. Radiotherapy was continued, achieving a good tumour response.
Cardiotoxicity is rarely reported with 5-FU. The cardiac events can be life threatening. It is difficult to predict which patients will be affected. Clinicians need to be aware of this potential toxicity and monitor patients appropriately.
报告3例癌症患者使用5-氟尿嘧啶（5-FU）后发生心脏毒性的病例。
3例胃肠道恶性肿瘤患者接受放疗和化疗联合方案治疗。2例患者在使用5-FU时出现心肌缺血，另1例出现室性心律失常。
所有患者均从心脏事件中存活。没有患者再次使用5-FU。放疗继续进行，肿瘤反应良好。
5-FU很少报告有心脏毒性。心脏事件可能危及生命。很难预测哪些患者会受到影响。临床医生需要意识到这种潜在毒性并对患者进行适当监测。
