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ω-芋螺毒素MVIIC可逆性抑制人N型钙通道以及钙流入鸡突触体。

Omega-conotoxin MVIIC reversibly inhibits a human N-type calcium channel and calcium influx into chick synaptosomes.

作者信息

Grantham C J, Bowman D, Bath C P, Bell D C, Bleakman D

机构信息

Lilly Research Centre Ltd, Windlesham, Surrey, U.K.

出版信息

Neuropharmacology. 1994 Feb;33(2):255-8. doi: 10.1016/0028-3908(94)90017-5.

DOI:10.1016/0028-3908(94)90017-5
PMID:8035912
Abstract

We have investigated the effects of omega-CmTX MVIIC on the recombinant alpha 1B-mediated calcium channel expressed in HEK 293 cells and on the predominantly N-type calcium channel in chick synaptosomes. omega-CmTX MVIIC potently and reversibly inhibited the calcium current through alpha 1B-mediated calcium channels and inhibited KCl-evoked increases in [Ca2+]i in chick synaptosomes in a concentration-dependent manner.

摘要

我们研究了ω-CmTX MVIIC对在HEK 293细胞中表达的重组α1B介导的钙通道以及鸡突触体中主要的N型钙通道的影响。ω-CmTX MVIIC有效且可逆地抑制通过α1B介导的钙通道的钙电流，并以浓度依赖性方式抑制鸡突触体中KCl诱发的[Ca2+]i升高。

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