Gilman J T, Duchowny M, Jayakar P, Resnick T J
Division of Clinical Pharmacology, Miami Children's Hospital, FL 33155-3098.
Neurology. 1994 Jul;44(7):1341-3. doi: 10.1212/wnl.44.7.1341.
We assessed the value of therapeutic reevaluation and additional pharmacotherapy in medically intractable children referred for epilepsy surgery. In 21 children with antiepileptic drug treatment omissions, correcting the omission was ineffective in 19 (90%). Two children (10%), both of whom had structural lesions, achieved significant seizure control with high-dose carbamazepine monotherapy. Therapeutic reevaluation is indicated in all medically intractable children prior to epilepsy surgery.
我们评估了在转介至癫痫手术的药物难治性儿童中进行治疗性重新评估和追加药物治疗的价值。在21例有抗癫痫药物漏服情况的儿童中，纠正漏服对19例（90%）无效。两名儿童（10%），均有结构性病变，通过高剂量卡马西平单药治疗实现了显著的癫痫发作控制。在所有药物难治性儿童进行癫痫手术前均需进行治疗性重新评估。
