Nelson C L, Hickmon S G, Harrison B H
Dept of Orthopedic Surgery, University of Arkansas Medical Sciences, Little Rock 72205.
Orthopedics. 1994 May;17(5):415-6. doi: 10.3928/0147-7447-19940501-06.
Seventeen patients had gentamicin-PMMA beads implanted for treatment of orthopedic infections. The authors found that beads implanted in patients for 3 to 36 weeks were capable of eluting high levels of antibiotic after retrieval. Beads that were implanted in patients for less than 10 weeks eluted significantly higher antibiotic levels than beads were implanted for more than 14 weeks. This study supports the local use of these beads in the treatment of musculoskeletal infections.
17名患者植入庆大霉素-聚甲基丙烯酸甲酯（PMMA）珠用于治疗骨科感染。作者发现，植入患者体内3至36周的珠子在取出后能够洗脱高水平的抗生素。植入患者体内少于10周的珠子洗脱的抗生素水平明显高于植入超过14周的珠子。这项研究支持在肌肉骨骼感染治疗中局部使用这些珠子。
