Trux F, Fink R, Wutke K
Folia Haematol Int Mag Klin Morphol Blutforsch. 1978;105(3):354-66.
Among 106 patients with Hodgkin's lymphoma in stage IIIB and IVB treated from September 1969 to June 1977 by a working team for hematology and oncology at the clinic and outpatients clinic of the Medical School of Erfurt, there were two cases (=1.9%) showing a final transition to leukaemia with immature cells. A third neoplasia which had developed in a former field of irradiation was additionally observed in one patient. The various possibilities arising from an oncologic effect of ionizing rays and those substances having a cytostatic effect are discussed. After frequent reports on the occurrence of secondary tumours following intensive radiological and cytostatic therapy of advanced Hodgkin's lymphoma the enhanced risk of a secondary tumour being induced by this combined therapy cannot be excluded. Various conclusions are drawn from that by the authors.
1969年9月至1977年6月期间，爱尔福特医学院临床及门诊血液学和肿瘤学工作团队对106例IIIB期和IVB期霍奇金淋巴瘤患者进行了治疗，其中有2例（1.9%）最终转变为伴有未成熟细胞的白血病。另外，在1例患者中还观察到在既往放疗区域发生了第三种肿瘤。本文讨论了电离辐射的肿瘤学效应以及具有细胞抑制作用的物质所产生的各种可能性。在频繁报道晚期霍奇金淋巴瘤经强化放疗和细胞抑制治疗后发生继发性肿瘤后，不能排除这种联合治疗诱发继发性肿瘤的风险增加。作者由此得出了各种结论。
