Mikhaĭlova L N, Osipenkova-Vichtomova T K
Sud Med Ekspert. 1993 Jan-Mar;36(1):12-7.
Histo- and ultrastructure of pathologically changed bone tissue in fibrous dysplasia was under study (9 cases were analyzed). Histologically a fibrous dysplasia focus is represented by cellular fibrous osteogenic tissue with scanty primitive coarse-fibrous bone structures. Ultrastructural changes evidence that these structures are formed at the edge of previous bone beams. Inadequate intraperiod fine structure of collagen fibrils does not provide a strong connection between hydroxyapatite crystals. These shifts result in functional inadequacy of bone tissue in fibrous dysplasia, that should be taken into consideration when assessing the severity of injury to osseous organs.
对纤维发育异常中病理改变的骨组织的组织学和超微结构进行了研究（分析了9例病例）。组织学上，纤维发育异常病灶表现为细胞性纤维成骨组织，伴有稀少的原始粗纤维骨结构。超微结构变化表明这些结构是在先前骨小梁边缘形成的。胶原纤维的周期内精细结构不完善，无法在羟基磷灰石晶体之间提供牢固连接。这些变化导致纤维发育异常中骨组织功能不足，在评估骨器官损伤的严重程度时应予以考虑。
