Kaasik A E, Kyĭv L E, Paiu A A, Tomberg T A, Merisalu E P, Tsil'mer K Ia
Zh Vopr Neirokhir Im N N Burdenko. 1994 Jan-Mar(1):26-9.
A total of 43 males with craniocerebral injury of varying severity were studied for the venous blood plasma levels of adrenaline, noradrenaline, adrenocorticotrophic hormone, and hydrocortisone in dynamics. Their computed tomograms were quantitatively analysed to identify the site of contusion foci in the cerebral hemispheres, especially the lesion signs of mesodiencephalic and truncal regions of the brain. The results of the studies and non-linear regression analysis have shown that brain injury leads to a substantial activation of the body's sympathoadrenal system, extremely severe injury causes its partial reduced performance. In severe and critical cerebrocranial injury, the central link of the hypothalamus-pituitary-adrenocortical system is exhausted and hydrocortisone release occurs without its control. The above changes depend on the size of hepatoma and edema of the cerebral hemispheres and on secondary lesion of the brain mesodiencephalic and truncal regions. The activity of the sympathoadrenal and hypothalamus-pituitary-adrenocortical system, which was observed over a week, tended to its gradual decrease.
共对43名不同严重程度的颅脑损伤男性患者的静脉血浆中肾上腺素、去甲肾上腺素、促肾上腺皮质激素和氢化可的松水平进行了动态研究。对他们的计算机断层扫描图像进行了定量分析，以确定脑半球挫伤灶的位置，尤其是中脑和脑干区域的病变迹象。研究结果和非线性回归分析表明，脑损伤会导致机体交感肾上腺系统的大量激活，极其严重的损伤会使其部分功能下降。在严重和危急的颅脑损伤中，下丘脑-垂体-肾上腺皮质系统的中枢环节耗竭，氢化可的松的释放不受控制。上述变化取决于脑半球血肿和水肿的大小以及脑的中脑和脑干区域的继发性损伤。观察一周的交感肾上腺和下丘脑-垂体-肾上腺皮质系统的活性呈逐渐下降趋势。
