Venturi F, Polidori C, De Caro G
Istituto di Farmacologia, Facoltà di Farmacia, Università di Camerino.
Acta Biomed Ateneo Parmense. 1993;64(1-2):33-8.
A[Sar1, Ile7] AngIII, an angiotensin III analogue apparently devoid of any affinity for vascular angiotensin II (AngII) receptors, inhibits AngII-induced drinking but neither affects cellular dehydration-induced drinking nor produces any intake of water in water replete rats, suggesting that the dipsogenic effect of AngII is not of vascular origin. Thus, [Sar1, Ile7] AngIII is an interesting tool to study the central effects of AngII.
[Sar1，Ile7]血管紧张素III，一种显然对血管紧张素II（AngII）受体没有任何亲和力的血管紧张素III类似物，可抑制AngII诱导的饮水，但既不影响细胞脱水诱导的饮水，也不会使饮水充足的大鼠产生任何饮水行为，这表明AngII的致渴作用并非源于血管。因此，[Sar1，Ile7]血管紧张素III是研究AngII中枢作用的一个有趣工具。
