Liao W J, Qu Z W, Zhang J T
Institute of Materia Medica, Chinese Academy of Medical Science, Beijing.
Yao Xue Xue Bao. 1994;29(1):24-7.
The affinities of L-n-butyl-scopolamine, DL-n-butyl-scopolamine and atropine for the M-cholinergic receptors of rat uterus were compared using radioligand binding assay. Results showed that the affinity of L-n-butyl-scopolamine for the M-receptors was similar to that of DL-n-butyl-scopolamine, but lower than that of atropine. In isolated rat uterus, L- and DL-n-butyl-scopolamine were found not to influence the automatic contraction but antagonize the contraction induced by acetylcholine with nearly the same PA2, although the PA2 of both compounds were still lower than that of atropine. Therefore, no difference between L- and DL-n-butyl-scopolamine in either biological activity or receptor affinity was observed.
采用放射性配体结合分析法比较了L-正丁基东莨菪碱、DL-正丁基东莨菪碱和阿托品对大鼠子宫M胆碱能受体的亲和力。结果表明，L-正丁基东莨菪碱对M受体的亲和力与DL-正丁基东莨菪碱相似，但低于阿托品。在离体大鼠子宫中，发现L-和DL-正丁基东莨菪碱虽不影响自发收缩，但拮抗乙酰胆碱诱导的收缩，其PA2几乎相同，尽管这两种化合物的PA2仍低于阿托品。因此，未观察到L-和DL-正丁基东莨菪碱在生物活性或受体亲和力方面存在差异。
