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失眠的非药物干预措施:治疗效果的荟萃分析

Nonpharmacological interventions for insomnia: a meta-analysis of treatment efficacy.

作者信息

Morin C M, Culbert J P, Schwartz S M

机构信息

Medical College of Virginia, Virginia Commonwealth University, Richmond 23298-0268.

出版信息

Am J Psychiatry. 1994 Aug;151(8):1172-80. doi: 10.1176/ajp.151.8.1172.

Abstract

OBJECTIVE

Because of the role of psychological factors in insomnia, the shortcomings of hypnotic medications, and patients' greater acceptance of nonpharmacological treatments for insomnia, the authors conducted a meta-analysis to examine the efficacy and durability of psychological treatments for the clinical management of chronic insomnia.

METHOD

A total of 59 treatment outcome studies, involving 2,102 patients, were selected for review on the basis of the following criteria: 1) the primary target problem was sleep-onset, maintenance, or mixed insomnia, 2) the treatment was nonpharmacological, 3) the study used a group design, and 4) the outcome measures included sleep-onset latency, time awake after sleep onset, number of nighttime awakenings, or total sleep time.

RESULTS

Psychological interventions, averaging 5.0 hours of therapy time, produced reliable changes in two of the four sleep measures examined. The average effect sizes (i.e., z scores) were 0.88 for sleep latency and 0.65 for time awake after sleep onset. These results indicate that patients with insomnia were better off after treatment than 81% and 74% of untreated control subjects in terms of sleep induction and sleep maintenance, respectively. Stimulus control and sleep restriction were the most effective single therapy procedures, whereas sleep hygiene education was not effective when used alone. Clinical improvements seen at treatment completion were well maintained at follow-ups averaging 6 months in duration.

CONCLUSIONS

The findings indicate that nonpharmacological interventions produce reliable and durable changes in the sleep patterns of patients with chronic insomnia.

摘要

目的

鉴于心理因素在失眠中的作用、催眠药物的缺点以及患者对失眠非药物治疗的更高接受度,作者进行了一项荟萃分析,以检验心理治疗对慢性失眠临床管理的疗效和持久性。

方法

根据以下标准,共筛选出59项涉及2102名患者的治疗结果研究进行综述:1)主要目标问题为入睡困难、睡眠维持困难或混合型失眠;2)治疗为非药物治疗;3)研究采用组间设计;4)结局指标包括入睡潜伏期、睡眠开始后的清醒时间、夜间觉醒次数或总睡眠时间。

结果

平均治疗时间为5.0小时的心理干预在四项检查的睡眠指标中的两项上产生了可靠的变化。入睡潜伏期的平均效应量(即z分数)为0.88,睡眠开始后的清醒时间为0.65。这些结果表明,失眠患者在治疗后的入睡和睡眠维持方面分别比81%和74%未治疗的对照受试者情况更好。刺激控制和睡眠限制是最有效的单一治疗方法,而单独使用睡眠卫生教育则无效。治疗结束时观察到的临床改善在平均为期6个月的随访中得到了很好的维持。

结论

研究结果表明,非药物干预可使慢性失眠患者的睡眠模式产生可靠且持久的变化。

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