Javitt D C, Zylberman I, Zukin S R, Heresco-Levy U, Lindenmayer J P
Department of Psychiatry, Albert Einstein College of Medicine, Bronx Psychiatric Center, NY 10461.
Am J Psychiatry. 1994 Aug;151(8):1234-6. doi: 10.1176/ajp.151.8.1234.
Phencyclidine induces a psychotomimetic state by blocking neurotransmission at N-methyl-D-aspartic acid (NMDA) receptors. In a double-blind, placebo-controlled fashion, 14 medicated patients with chronic schizophrenia were treated with glycine, a potentiator of NMDA-receptor-mediated neurotransmission. Significant improvement in negative symptoms occurred in the group given glycine but not in the group given placebo, suggesting that potentiation of NMDA-receptor-mediated neurotransmission may represent an effective treatment for neuroleptic-resistant negative symptoms in schizophrenia.
苯环己哌啶通过阻断N-甲基-D-天冬氨酸（NMDA）受体处的神经传递来诱发拟精神病状态。在一项双盲、安慰剂对照试验中，14名患有慢性精神分裂症且正在服药的患者接受了甘氨酸治疗，甘氨酸是NMDA受体介导的神经传递的增强剂。接受甘氨酸治疗的组中阴性症状有显著改善，而接受安慰剂治疗的组则没有，这表明增强NMDA受体介导的神经传递可能是治疗精神分裂症中对抗精神病药物耐药的阴性症状的一种有效方法。
