身高体重指标对急性淋巴细胞白血病患儿有预后意义吗？

Does weight for height have prognostic significance in children with acute lymphoblastic leukemia?

作者信息

Reilly J J, Odame I, McColl J H, McAllister P J, Gibson B E, Wharton B A

机构信息

Department of Human Nutrition, University of Glasgow, Yorkhill Hospitals, Scotland.

出版信息

Am J Pediatr Hematol Oncol. 1994 Aug;16(3):225-30. doi: 10.1097/00043426-199408000-00007.

DOI:10.1097/00043426-199408000-00007

PMID:8037340

Abstract

PURPOSE

We tested the hypothesis that weight for height, a simple index of nutritional status, is related to prognosis in childhood acute lymphoblastic leukemia (ALL).

PATIENTS AND METHODS

The study population was composed of 78 children with ALL tested at one U.K. center on the same protocol (UKALL-X). Outcome measures were relapse/no relapse and time to first relapse. Influence of weight for height, expressed as standard deviation scores, was tested using survival analysis in a retrospective design.

RESULTS

The weight-for-height standard deviation score had a significant influence on time until first relapse (log ranks test, p = 0.012), with the highest risk of early relapse in children at the lower end of the weight-for-height distribution.

CONCLUSIONS

The results suggest that weight for height does have an influence on outcome in ALL, but the mechanism is unclear and the finding requires confirmation by larger scale prospective studies.

摘要