没有证据表明急性淋巴细胞白血病患儿诊断时的营养状况对预后有影响。
No evidence for an effect of nutritional status at diagnosis on prognosis in children with acute lymphoblastic leukemia.
作者信息
Weir J, Reilly J J, McColl J H, Gibson B E
机构信息
University of Glasgow, Department of Human Nutrition, Yorkhill NHS Trust, Scotland, UK.
出版信息
J Pediatr Hematol Oncol. 1998 Nov-Dec;20(6):534-8. doi: 10.1097/00043426-199811000-00004.
PURPOSE
To test the hypothesis that nutritional status at diagnosis, defined as body mass index standard deviation score (SDS), is related to the prognosis in childhood acute lymphoblastic leukemia (ALL).
PATIENTS AND METHODS
The sample consisted of 1,025 patients with standard risk ALL who had been randomized to different intensification therapies. Outcome measures were relapse/no relapse and time to first relapse. The influence of body mass index SDS was tested by survival analysis.
RESULTS
There was no evidence that body mass index SDS was related to clinical outcome (proportional hazards model, p = 0.72).
CONCLUSIONS
The study results suggest that nutritional status at diagnosis, defined on the basis of the body mass index, at least in developed countries, has no effect on the prognosis in ALL, and it should not be considered as a prognostic factor.
目的
检验如下假设，即诊断时的营养状况（定义为体重指数标准差评分[SDS]）与儿童急性淋巴细胞白血病（ALL）的预后相关。
患者与方法
样本包括1025例标准风险ALL患者，这些患者已被随机分配至不同的强化治疗方案。结局指标为复发/未复发以及首次复发时间。通过生存分析检验体重指数SDS的影响。
结果
没有证据表明体重指数SDS与临床结局相关（比例风险模型，p = 0.72）。
结论
研究结果表明，至少在发达国家，基于体重指数定义的诊断时营养状况对ALL的预后没有影响，不应将其视为预后因素。
Zotero 插件