Fedorova Z F
Antibiot Khimioter. 1993 Aug-Sep;38(8-9):42-3.
Possible L-transformation of Shigella under the action of biseptol on an artificial nutrient medium was investigated. The L-forms were isolated from 6 out of 35 cultures. By the morphological properties the isolates were similar to the L-forms of Shigella flexneri induced by furazolidone. The growth of the L-forms proceeded by the pattern of the rapid mass L-conversion of bacteria and was accompanied by the development of resistance to biseptol. It was inhibited by folic acid added to the medium.
研究了在双嘧啶作用下,志贺氏菌在人工营养培养基上可能发生的L型转化。从35个培养物中的6个分离出了L型。根据形态学特性,分离物与由呋喃唑酮诱导的弗氏志贺氏菌L型相似。L型的生长以细菌快速大量L型转化的模式进行,并伴随着对双嘧啶耐药性的产生。添加到培养基中的叶酸可抑制其生长。