Saslow A R, Hammon W M, Rycheck R R, Streiff E, Lewis J
Am J Epidemiol. 1975 Mar;101(3):211-9. doi: 10.1093/oxfordjournals.aje.a112088.
An epidemiologic investigation of viral hepatitis among "street-people" was conducted in Pittsburgh, PA in 1971. Among 146 individuals, 100 admitted to parenteral drug use and 73 (50%) had evidence of acute viral hepatitis. Counterelectrophoresis (CEP) and complement-fixation (CF) were used to test for type B antigen (HBS AG). Seventeen individuals (22%) had detectable HBSAG; 13 of these were clinically ill and admitted to drug use, Type B antibody (anti-HBS) was tested for by CEP and radioimmunoprecipitation (RIP). Thirty-five persons (29%), 15 of whom admitted to drug use and were ill, had detectable antibody by RIP; none had detectable antibody by CEP. None of those tested had both HBSAB and anti-HBS Evidence to support the hypothesis of sexual transmission of type B virus was found. Use of prophylactic gamma globulin in street-people populations is recommended.
1971年在宾夕法尼亚州匹兹堡市对“街头人群”中的病毒性肝炎进行了一项流行病学调查。在146名个体中，100人承认有非肠道药物使用史，73人（50%）有急性病毒性肝炎的证据。采用对流免疫电泳（CEP）和补体结合（CF）试验检测B型抗原（HBS AG）。17人（22%）可检测到HBSAG；其中13人有临床症状且承认有药物使用史。采用CEP和放射免疫沉淀法（RIP）检测B型抗体（抗-HBS）。35人（29%）可通过RIP检测到抗体，其中15人承认有药物使用史且患病；通过CEP均未检测到抗体。所有检测者均未同时检测到HBSAB和抗-HBS。未发现支持B型病毒性传播假说的证据。建议在街头人群中使用预防性γ球蛋白。
