Goplerud J M, Delivoria-Papadopoulos M
Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia 19104.
Biol Neonate. 1994;65(3-4):220-30. doi: 10.1159/000244056.
The effect of theophylline on cerebral blood flow (CBF), oxygen transport, and energy metabolism was investigated during and following brief episodes of asphyxia. CBF was determined by microspheres during control, asphyxia, and recovery with reventilation after a single asphyxia (recovery I) and after 7 repeated asphyxias (recovery II). In addition, cerebral energy metabolism by 31P NMR spectroscopy and cerebral oxygen consumption (CMRO2) in newborn piglets treated with 30 mg/kg theophylline (serum levels 22-25 micrograms/ml) were compared with nontreated piglets. Theophylline increased CMRO2 during recovery I (348 mumol O2/min/100 g vs. 144 for non-theophylline) but not during control, asphyxia, or recovery II. There was no significant difference between the theophylline and non-theophylline groups in depletion of phosphoenergetics as measured by 31P NMR.
研究了氨茶碱在短暂窒息期间及之后对脑血流量（CBF）、氧运输和能量代谢的影响。在对照、窒息以及单次窒息（恢复I）和7次重复窒息（恢复II）后再通气恢复期间，通过微球测定CBF。此外，将用30mg/kg氨茶碱（血清水平22 - 25μg/ml）治疗的新生仔猪与未治疗的仔猪进行比较，通过31P核磁共振波谱法测定脑能量代谢和脑氧消耗（CMRO2）。氨茶碱在恢复I期间增加了CMRO2（348μmol O2/分钟/100g，未用氨茶碱的为144），但在对照、窒息或恢复II期间未增加。通过31P核磁共振测量，氨茶碱组和未用氨茶碱组在磷酸能量消耗方面没有显著差异。
