Smith S L, Gottlieb S F
Aviat Space Environ Med. 1975 Feb;46(2):161-9.
The objective of this investigation was to study the effects of increased oxygen pressures on the development of Drosophila melanogaster. Oxygen is a potent inhibitor of embryonic and post-embryonic development of Drosophila. The lowest partial pressure of O2 (Po2) found to elicit measurable inhibitory effects on development is 0.6 ATA. Continuous exposure of developing Drosophila to 0.6 ATA O2 elicits primarily a larvicidal effect; surviving larvae exhibit delays in initial puparium formation and in mean day of adult eclosion: several resultant adults exhibit the effects of O2-induced teratogenesis in that body and wing abnormalities become manifest which do not breed true on matings and back crosses. Continuous exposure to 0.8 or 1.0 ATA O2 results in developmental arrest in the second larval instar followed by death. This development arrest is reversible depending upon the duration of exposure. As concerns lethality, early larval stages are more sensitive to O2 than late larval stages which, in turn, are more sensitive than early or late pupal stages: the embryo is the more resistant of the development stages. As concerns sensitivity for teratogenesis, the embryo is the most sensitive stage.
本研究的目的是探究氧气压力增加对黑腹果蝇发育的影响。氧气是果蝇胚胎发育和胚后发育的一种强效抑制剂。已发现对发育产生可测量抑制作用的最低氧分压（Po2）为0.6ATA。将发育中的果蝇持续暴露于0.6ATA的氧气中主要会产生杀幼虫作用；存活的幼虫在初始化蛹和成虫羽化平均日方面出现延迟：一些羽化出的成虫表现出氧气诱导的致畸作用，即身体和翅膀出现异常，这些异常在交配和回交时不会真实遗传。持续暴露于0.8或1.0ATA的氧气中会导致第二龄幼虫发育停滞，随后死亡。这种发育停滞取决于暴露持续时间，是可逆的。关于致死率，幼虫早期阶段比晚期幼虫阶段对氧气更敏感，而晚期幼虫阶段又比早期或晚期蛹期更敏感：胚胎是发育阶段中抵抗力最强的。关于致畸敏感性，胚胎是最敏感的阶段。
