Litz C E, Brunning R D
Laboratory Medicine and Pathology, University of Minnesota Medical School, University of Minnesota Hospital, MN 55455.
Baillieres Clin Haematol. 1993 Dec;6(4):767-83. doi: 10.1016/s0950-3536(05)80175-1.
The chronic lymphoproliferative disorders are morphologically, immunologically and clinically heterogeneous. Common features of these processes include T, B or natural killer cell immunophenotypes and terminal deoxy-nucleotidyl transferase negativity. The B cell lymphocytic disorders include B-chronic lymphocytic leukaemia, B cell prolymphocytic leukaemia, chronic lymphocytic leukaemia-prolymphocytic leukaemia, non-Hodgkin's lymphoma (including mantle cell lymphoma) in leukaemic phase, hairy cell leukaemia and splenic lymphoma with villous lymphocytes. The T cell chronic lymphoproliferative disorders include prolymphocytic leukaemia, adult T cell leukaemia-lymphoma, large granulated lymphocyte leukaemia and Sézary syndrome. Occasionally, a lymphocytic proliferation is encountered that does not satisfy the morphological or immunophenotypical criteria for any of the above categories. These processes are best left unclassified.
慢性淋巴细胞增殖性疾病在形态学、免疫学和临床方面具有异质性。这些病变过程的共同特征包括T、B或自然杀伤细胞免疫表型以及末端脱氧核苷酸转移酶阴性。B细胞淋巴细胞疾病包括B慢性淋巴细胞白血病、B细胞幼淋巴细胞白血病、慢性淋巴细胞白血病-幼淋巴细胞白血病、白血病期非霍奇金淋巴瘤（包括套细胞淋巴瘤）、毛细胞白血病和伴绒毛状淋巴细胞的脾淋巴瘤。T细胞慢性淋巴细胞增殖性疾病包括幼淋巴细胞白血病、成人T细胞白血病-淋巴瘤、大颗粒淋巴细胞白血病和Sezary综合征。偶尔会遇到一种淋巴细胞增殖，它不符合上述任何一类的形态学或免疫表型标准。这些病变过程最好不做分类。
