Coit D G
Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
Melanoma Res. 1994 Mar;4 Suppl 1:57-60.
The current review summarizes briefly the reported limitations of the literature on isolation limb perfusion for melanoma, as well as current clinical research in the use of this modality. The most intriguing advance has been the combination of the cytokine tumour necrosis factor with melphalan; this has yielded a consistent complete response rate of 90%. Not all responses remain durable, and the impact of this very effective combination but potentially toxic regimen on patient survival remains to be shown. Future challenges in the field are proposed.
本综述简要总结了已报道的关于黑色素瘤隔离肢体灌注文献的局限性，以及该方法目前的临床研究情况。最引人关注的进展是细胞因子肿瘤坏死因子与美法仑的联合应用；这已产生了90%的持续完全缓解率。并非所有缓解都能持久，这种非常有效的联合但可能有毒性的方案对患者生存的影响仍有待证实。文中还提出了该领域未来面临的挑战。
