Wazer D E, Erban J K, Robert N J, Smith T J, Marchant D J, Schmid C, DiPetrillo T, Schmidt-Ullrich R
Breast Health Center, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111.
Cancer. 1994 Aug 1;74(3):878-83. doi: 10.1002/1097-0142(19940801)74:3<878::aid-cncr2820740314>3.0.co;2-4.
A prospective study was initiated to explore an approach of limited therapy in elderly patients with early clinical stage breast cancer.
Between 1982 and 1989, 73 women with American Joint Committee on Cancer Stage I/II, clinically negative axillary lymph nodes aged 65 years or older (median age, 74 years) were enrolled in a treatment program consisting of tumor excision, breast and regional lymph node irradiation, and, in 66 patients, tamoxifen. Patients were assessed for disease outcome and complications.
At a median follow-up of 54 months, 8-year rates of local and regional lymph node control were 92.5% and 100%, respectively. Eight-year probabilities of disease free, overall, and breast cancer specific survival were 84%, 52.5%, and 93.8%, respectively. There was minimal morbidity associated with either regional irradiation or tamoxifen.
An approach to early breast cancer in the elderly that seeks to limit the aggressiveness of local and systemic therapies appears to result in a satisfactory disease outcome with few complications.
开展了一项前瞻性研究，以探索老年早期临床阶段乳腺癌患者的有限治疗方法。
1982年至1989年期间，73例美国癌症联合委员会分期为I/II期、临床腋窝淋巴结阴性、年龄65岁及以上（中位年龄74岁）的女性纳入了一个治疗方案，该方案包括肿瘤切除、乳房及区域淋巴结放疗，66例患者还接受了他莫昔芬治疗。对患者的疾病转归和并发症进行评估。
中位随访54个月时，局部和区域淋巴结8年控制率分别为92.5%和100%。无病、总生存和乳腺癌特异性生存的8年概率分别为84%、52.5%和93.8%。区域放疗或他莫昔芬相关的发病率均极低。
一种旨在限制局部和全身治疗激进程度的老年早期乳腺癌治疗方法似乎能带来令人满意的疾病转归，且并发症较少。
