神经节苷脂在溶液中的聚集特性。

Aggregative properties of gangliosides in solution.

作者信息

Sonnino S, Cantù L, Corti M, Acquotti D, Venerando B

机构信息

Department of Medical Chemistry and Biochemistry, University of Milan, Medical School, Italy.

出版信息

Chem Phys Lipids. 1994 May 6;71(1):21-45. doi: 10.1016/0009-3084(94)02304-2.

DOI:10.1016/0009-3084(94)02304-2

PMID:8039256

Abstract

The aggregative properties of gangliosides in diluted aqueous solutions are discussed on the basis of simple and well-established thermodynamic concepts. Theoretical assumptions are compared with experimental data obtained, mainly by scattering techniques, on GM3, GM2, GM1, GD1a, GalNAc-GD1a, GD1b, GD1b lactone and GT1b gangliosides, all containing ceramide portions of similar composition, and on GM1 molecular species containing different well-defined ceramide structures. We also report on mixed aggregates with amphiphilic compounds and on the ganglioside aggregate-soluble protein interaction effects which give rise to very stable lipoproteic complexes of well-defined ganglioside-protein composition.

摘要

基于简单且成熟的热力学概念，讨论了神经节苷脂在稀水溶液中的聚集性质。将理论假设与主要通过散射技术获得的实验数据进行了比较，这些实验数据涉及GM3、GM2、GM1、GD1a、GalNAc-GD1a、GD1b、GD1b内酯和GT1b神经节苷脂，它们都含有组成相似的神经酰胺部分，以及含有不同明确神经酰胺结构的GM1分子种类。我们还报告了与两亲化合物的混合聚集体以及神经节苷脂聚集体-可溶性蛋白质相互作用效应，这些效应产生了具有明确神经节苷脂-蛋白质组成的非常稳定的脂蛋白复合物。