Niël C G, Koper P C, Visser A G, Sipkema D, Levendag P C
Dr. Daniel den Hoed Cancer Center, Department of Radiation Oncology, Rotterdam, The Netherlands.
Int J Radiat Oncol Biol Phys. 1994 Jul 1;29(4):873-7. doi: 10.1016/0360-3016(94)90579-7.
No adequate high dose rate brachytherapy technique exists to cover all known tumor volume by using one type of applicator in patients presenting with a cervix carcinoma extending to the vaginal wall and the parametria.
We adapted the existing high dose rate applicator, existing of two ovoids and one intrauterine tube, to achieve adequate irradiation of the uterus, the parametria, and the vaginal wall in these patients. Using the optimization program of the Nucletron Planning System, isodose curves were obtained to apply a specified dose of 8.5 Gy at point A and at 5 mm depth of the vaginal wall by using a single applicator for both fractions.
Fractionated high dose rate brachytherapy can be given with both higher dosimetric accuracy and more adequate irradiation of the vaginal and the parametrial tumor component after adapting the existing high dose rate applicator for brachytherapy in cervical cancer.
对于宫颈癌累及阴道壁和宫旁组织的患者，目前尚无足够的高剂量率近距离放疗技术能够通过使用一种施源器覆盖所有已知肿瘤体积。
我们对现有的由两个卵圆形施源器和一个宫腔管组成的高剂量率施源器进行了改进，以实现对这些患者的子宫、宫旁组织和阴道壁进行充分照射。使用Nucletron治疗计划系统的优化程序，通过对两个分割剂量均使用单个施源器，获得等剂量曲线，以在A点和阴道壁5毫米深度处施加8.5 Gy的指定剂量。
在对现有的用于宫颈癌近距离放疗的高剂量率施源器进行改进后，可进行分次高剂量率近距离放疗，且剂量学准确性更高，对阴道和宫旁肿瘤成分的照射也更充分。
