中耳肌肉在抵抗噪声性听力损失发展过程中的作用。

The role of middle ear muscles in the development of resistance to noise induced hearing loss.

作者信息

Henderson D, Subramaniam M, Papazian M, Spongr V P

机构信息

Department of Communicative Disorders and Sciences, State University of New York, Buffalo 14214.

出版信息

Hear Res. 1994 Apr;74(1-2):22-8. doi: 10.1016/0378-5955(94)90172-4.

DOI:10.1016/0378-5955(94)90172-4

PMID:8040091

Abstract

The role of middle ear muscles (MEMs) in the development of increased resistance to noise induced hearing loss (NIHL) was studied using monaural chinchillas. Animals with severed MEMs as well as those with intact MEMs were exposed to an octave band noise (OBN) centered at 0.5 kHz at 95 dB for six hours/day for ten consecutive days. Results indicated that animals with severed MEMs showed greater initial threshold shifts (TS) than the animals with intact MEMs. Both the groups showed a decrease in TS over the ten days of exposure. The subjects were given five days of recovery and then re-exposed to the same noise at 106 dB for 48 h. Permanent threshold shifts (PTS) in each group was compared against those in a control group exposed to the noise only at the higher level. Interestingly, both the 'conditioned' groups incurred substantially less PTS than the control group exposed only to the higher level.

摘要

使用单耳龙猫研究了中耳肌肉（MEMs）在增强对噪声性听力损失（NIHL）抵抗力发展中的作用。切断中耳肌肉的动物以及中耳肌肉完整的动物，每天暴露于以0.5 kHz为中心、95分贝的倍频程带噪声（OBN）中，持续6小时，连续10天。结果表明，切断中耳肌肉的动物比中耳肌肉完整的动物表现出更大的初始阈值偏移（TS）。两组在暴露的十天内TS均有所下降。让这些实验对象恢复五天，然后再次暴露于106分贝的相同噪声中48小时。将每组的永久性阈值偏移（PTS）与仅在较高水平暴露于噪声的对照组进行比较。有趣的是，两个“预处理”组的PTS都比仅暴露于较高水平的对照组少得多。