Cell membrane, a target for PUVA therapy.

The photochemical reactions occurring in the cell membranes, sensitized photo-oxidation and psoralen photoaddition to lipids, are briefly reviewed. Phospholipid dynamics in the membrane structure, based on erythrocyte lipid organization, are described. Evidence for alterations of cell membrane functions under psoralen plus UVA radiation (PUVA) treatment in a variety of mammalian cells is presented. Cell receptor dysfunctions under PUVA treatment are demonstrated in a number of biological investigations. The purpose of this survey is to illustrate the feasibility of studying psoralen photobiology with phospholipids. The reaction of psoralens with phospholipids is considered to be one of the triggering mechanisms of the subsequent physiological responses, which may be relevant to PUVA photochemotherapy.