Anyaegbunam A, Edwards C
Department of Obstetrics and Gynecology, Albert Einstein College of Medicine, Bronx, New York 10461.
J Natl Med Assoc. 1994 Apr;86(4):289-93.
Hypertension, which is the most common complication of pregnancy, is a leading cause of both maternal and perinatal morbidity. Advances in research related to hypertensive disorders in pregnancy have facilitated a better general understanding of the pathophysiologic processes associated with this disease. Strategies of prevention, early diagnosis, and newer treatments have contributed to a more favorable outcome for mothers and their babies. The exact cause of preeclampsia remains elusive; however, recent investigations suggest that endothelial cell injury due to free radical-mediated lipid peroxidation may be the initiator of the pathophysiologic events of preeclampsia. Future challenges in this area should include efforts to elucidate mechanisms involved in free radical cell-mediated vascular disturbances and antioxidant defenses.
高血压是妊娠最常见的并发症，是孕产妇和围产期发病的主要原因。妊娠高血压疾病相关研究的进展有助于更全面地了解与该疾病相关的病理生理过程。预防、早期诊断和新治疗策略有助于母亲及其婴儿获得更有利的结局。子痫前期的确切病因仍不清楚；然而，最近的研究表明，自由基介导的脂质过氧化引起的内皮细胞损伤可能是子痫前期病理生理事件的起始因素。该领域未来的挑战应包括努力阐明自由基细胞介导的血管紊乱和抗氧化防御所涉及的机制。
