Yamada T, Oinuma T, Sakurai I, Saitoh E, Fujioka T, Tochihara T
Second Department of Pathology, Nihon University School of Medicine.
Nihon Ronen Igakkai Zasshi. 1994 Apr;31(4):279-84. doi: 10.3143/geriatrics.31.279.
A total of 161 atherosclerotic plaques from 50 aortas in elderly autopsy cases were pathomorphologically investigated to clarify the pathogenesis of atherosclerotic plaque with central depression. Atherosclerotic plaques with central depression, with well defined borders were employed for this study, ulcerated plaques being excluded. Pathomorphological findings showed that plaques with central depression could be divided into four groups according to their derivation respectively; (a) fused lesion of multiple fibrous plaque, (b) regressing lesion of plaque, (c) healing lesion of ulcerated atheromatous plaque, (d) mixed type. Finally, it was suggested that atherosclerotic regression may cause some central depression in the atheromatous plaques.
对50例老年尸检病例的主动脉中总共161个动脉粥样硬化斑块进行了病理形态学研究，以阐明伴有中央凹陷的动脉粥样硬化斑块的发病机制。本研究采用边界清晰的伴有中央凹陷的动脉粥样硬化斑块，排除溃疡斑块。病理形态学结果显示，伴有中央凹陷的斑块可根据其来源分为四组：(a)多个纤维斑块融合病变；(b)斑块消退病变；(c)溃疡粥样斑块愈合病变；(d)混合型。最后，提示动脉粥样硬化消退可能导致粥样斑块出现一些中央凹陷。
