Yasuhara O, Kawamata T, Aimi Y, McGeer E G, McGeer P L
Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, Canada.
Neurosci Lett. 1994 Mar 28;170(1):13-6. doi: 10.1016/0304-3940(94)90227-5.
Expression of chromogranin A in various neurological diseases was examined immunohistochemically using purified anti-human chromogranin A antiserum. The antibody stained dystrophic neurites in senile plaques in Alzheimer disease brain, Pick bodies and ballooned neurons in Pick's disease brain, some Lewy bodies in the substantia nigra of Parkinson's disease, and axonal swellings in various neurological conditions including Parkinson's disease, striatonigral degeneration, Shy-Drager syndrome, amyotrophic lateral sclerosis and cerebral infarction. The present study shows that expression of chromogranin A is not an exclusive feature of Alzheimer disease or Pick's disease, and indicates that it could be a useful marker for various neurological diseases.
使用纯化的抗人嗜铬粒蛋白A抗血清，通过免疫组织化学方法检测了嗜铬粒蛋白A在各种神经疾病中的表达。该抗体可使阿尔茨海默病脑内老年斑中的营养不良性神经突、匹克病脑内的匹克小体和气球样神经元、帕金森病黑质中的一些路易小体，以及包括帕金森病、纹状体黑质变性、Shy-Drager综合征、肌萎缩侧索硬化症和脑梗死在内的各种神经疾病中的轴突肿胀染色。本研究表明，嗜铬粒蛋白A的表达并非阿尔茨海默病或匹克病的独有特征，并表明它可能是各种神经疾病的有用标志物。
