McCrea S, Shuaib A, Wishart T, Ijaz S
Department of Psychology, Faculty of Medicine, University of Saskatchewan, Saskatoon, Canada.
Neurosci Lett. 1994 Mar 28;170(1):133-5. doi: 10.1016/0304-3940(94)90257-7.
Repetitive ischemia causes more severe damage than a single insult of comparable duration. Gerbils were followed for 1 month postrepetitive ischemia and 100% mortality was demonstrated in the unprotected ischemia group by 12 days postischemia. Significant protection against mortality due to repetitive ischemia was offered by both CGS-19755 and combination CGS-19755-hypothermia treatments. Current practices of sacrificing repetitive ischemia subjects shortly postischemia may lead to an underestimation of the effects of ischemia and/or an overestimation of the protective effects of experimental treatments.
重复性缺血比同等持续时间的单次损伤造成更严重的损害。对沙鼠进行重复性缺血后随访1个月，未受保护的缺血组在缺血后12天死亡率达100%。CGS-19755以及CGS-19755与低温联合治疗均对重复性缺血导致的死亡有显著保护作用。目前在缺血后不久就处死重复性缺血实验对象的做法可能会导致对缺血影响的低估和/或对实验治疗保护作用的高估。
