Gueritaud J P
Unité de Neurocybernétique Cellulaire, CNRS UPR-418, Marseille, France.
Neurosci Lett. 1994 Mar 28;170(1):158-62. doi: 10.1016/0304-3940(94)90263-1.
Intracellular recordings were obtained from adult rat oculomotor neurones in an in vitro brainstem slice preparation. In motoneurones hyperpolarized to levels below -90 mV, depolarizing current injections induced voltage-dependent low-threshold plateau potentials. These potentials were triggered at rest when charge transfer through Ca2+ channels was increased by Ba2+ substitution. In such conditions, the membrane displayed voltage-dependent bistable properties similar to those described in other preparations and shown in vivo to be under neurotransmitter control. These results show that increasing inward currents in adult oculomotor neurones of the rat induce functionally different responses to slight shifts of membrane potential.
在体外脑干切片制备中，从成年大鼠动眼神经神经元获取细胞内记录。在超极化至低于 -90 mV 水平的运动神经元中，去极化电流注入诱导电压依赖性低阈值平台电位。当通过 Ba2+ 替代增加通过 Ca2+ 通道的电荷转移时，这些电位在静息时被触发。在这种情况下，膜表现出与其他制备中描述的以及在体内显示受神经递质控制的类似的电压依赖性双稳态特性。这些结果表明，增加成年大鼠动眼神经神经元的内向电流会诱导对膜电位轻微变化产生功能不同的反应。
