Chang A Y, Kuo T B, Chan S H
Institute of Pharmacology, National Yang-Ming Medical College, Taipei, Taiwan, ROC.
Neurosci Lett. 1994 Mar 28;170(1):175-8. doi: 10.1016/0304-3940(94)90267-4.
Whereas it is well-known that cocaine induces EEG desynchronization and behavioral excitation in animals and human subjects, the detailed effect of cocaine on EEG activity remains to be fully elucidated. This communication reports our attempts in quantifying the effect of cocaine on EEG signals recorded from the somatosensory cortex of adult male Sprague-Dawley rats under chloral hydrate anesthesia (400 mg/kg i.p.). Continuous, on-line and real-time power spectral analysis revealed that i.v. administration of two doses of cocaine (1.5 or 3.0 mg/kg) dose-dependently induced EEG desynchronization, as indicated by a decrease in the root mean square and an increase in the mean power frequency values. More interestingly, whereas both doses of cocaine promoted a reduction in the alpha (8-13 Hz), theta (4-8 Hz) and delta (1-4 Hz) spectral components, the beta band (13-32 Hz) underwent differential alterations. The lower dose of cocaine elicited a transient increase, followed by a decrease in the power of the beta band. A prolonged increase in the power of the beta band, on the other hand, was observed after the higher dose of cocaine. These results suggest that subtle changes in the individual EEG spectral components, which are dose-dependent, may underlie the EEG desynchronization induced by cocaine.
众所周知，可卡因会在动物和人类受试者中诱发脑电图去同步化和行为兴奋，但可卡因对脑电图活动的具体影响仍有待充分阐明。本通讯报道了我们在水合氯醛麻醉（腹腔注射400mg/kg）下，对成年雄性Sprague-Dawley大鼠体感皮层记录的脑电图信号进行可卡因效应量化的尝试。连续、在线和实时功率谱分析显示，静脉注射两剂可卡因（1.5或3.0mg/kg）剂量依赖性地诱发脑电图去同步化，表现为均方根降低和平均功率频率值增加。更有趣的是，虽然两剂可卡因都促使α（8-13Hz）、θ（4-8Hz）和δ（1-4Hz）频谱成分减少，但β波段（13-32Hz）出现了不同的变化。较低剂量的可卡因引起β波段功率短暂增加，随后降低。另一方面，较高剂量的可卡因后观察到β波段功率持续增加。这些结果表明，可卡因诱发的脑电图去同步化可能是由个体脑电图频谱成分的细微变化引起的，且这些变化具有剂量依赖性。
