人类肿瘤特异性核仁蛋白P120中rRNA甲基转移酶结构域的预测。
Prediction of an rRNA methyltransferase domain in human tumor-specific nucleolar protein P120.
作者信息
Koonin E V
机构信息
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894.
出版信息
Nucleic Acids Res. 1994 Jul 11;22(13):2476-8. doi: 10.1093/nar/22.13.2476.
Abstract
Using computer methods for identification of amino acid motifs in sequence databases and multiple alignment, it is shown that human proliferation-associated nucleolar protein P120 contains a putative methyltransferase domain that is conserved in a group of bacterial proteins. It is hypothesized that P120 and the related prokaryotic proteins are rRNA methylases required for division of all types of cells.
摘要
利用计算机方法在序列数据库中识别氨基酸基序并进行多序列比对，结果表明，人类增殖相关核仁蛋白P120含有一个假定的甲基转移酶结构域，该结构域在一组细菌蛋白中保守。据推测，P120和相关的原核蛋白是所有类型细胞分裂所需的rRNA甲基化酶。
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