Gmoshinskiĭ I V, Mazo V K, Vasilevskaia L S
Vopr Pitan. 1993 Oct-Dec(5):45-50.
Gastrointestinal macromolecular permeability for polyethylene glycol (PEG)-4000 was studied in Wistar rats with resected distal portion of the small intestine, experimental colitis induced by chemical toxicant (acetic acid) and in rats receiving oral ethyl alcohol. Gastrointestinal permeability in animals with resection transiently increased during the first two weeks after operation and returned to normal thereafter. Colitis induction resulted in marked (2.5-fold) growth of permeability for PEG-4000 on day 7 and in a less significant increase on day 21. In animals exposed to ethyl alcohol no changes in macromolecular permeability were noted for PEG-4000 and food protein (chick's egg albumin). It is concluded that the model of colitis induced by chemical toxicants is most suitable among the models tested for experimental research on dietetic correction of altered macromolecular permeability.
在切除小肠远端部分的Wistar大鼠、由化学毒物（乙酸）诱导的实验性结肠炎大鼠以及口服乙醇的大鼠中，研究了聚乙二醇（PEG）-4000的胃肠道大分子通透性。切除术后的动物，其胃肠道通透性在术后前两周短暂增加，此后恢复正常。诱导结肠炎导致第7天PEG-4000的通透性显著（2.5倍）增加，第21天增加幅度较小。在接触乙醇的动物中，未观察到PEG-4000和食物蛋白（鸡卵清蛋白）的大分子通透性有变化。得出的结论是，在测试的模型中，化学毒物诱导的结肠炎模型最适合用于对改变的大分子通透性进行饮食纠正的实验研究。
