Miyata H, Hironaka N, Ando K, Yanagita T
Preclinical Research Division, Central Institute for Experimental Animals, Kawasaki, Japan.
Nihon Shinkei Seishin Yakurigaku Zasshi. 1994 Apr;14(2):111-5.
The purpose of this study was to compare the ability of intravenously administered methamphetamine and cocaine to facilitate dopaminergic transmission, based on the ability of these drugs to induce rotational behavior in rats with unilateral 6-hydroxydopamine lesions of the substantia nigra. The doses of methamphetamine and cocaine ranged from 0.25 mg/kg to 4 mg/kg which was equivalent to 50% of the minimum dose which caused convulsion. Methamphetamine induced more marked ipsilateral rotational behavior than did cocaine. The present results suggest that methamphetamine produces longer duration of the facilitation of dopaminergic transmission both in the nucleus accumbens and in the striatum than does cocaine.
本研究的目的是基于甲基苯丙胺和可卡因诱导单侧黑质6-羟基多巴胺损伤大鼠旋转行为的能力，比较静脉注射这两种药物促进多巴胺能传递的能力。甲基苯丙胺和可卡因的剂量范围为0.25mg/kg至4mg/kg，这相当于引起惊厥的最小剂量的50%。甲基苯丙胺比可卡因诱导出更明显的同侧旋转行为。目前的结果表明，与可卡因相比，甲基苯丙胺在伏隔核和纹状体中促进多巴胺能传递的持续时间更长。
