Wolf P
Zh Nevrol Psikhiatr Im S S Korsakova. 1993;93(1):36-8.
Determination of antiepileptic drug serum levels is today one of the most helpful aids in epilepsy therapy. Reference to "therapeutic ranges" should be abstained from the individual case where they are, at best, useless, but often misleading. The most important determinations are those immediately following a seizure because they are indispensible to establish the individual therapeutic threshold, and to elucidate the causes of seizure relapse. A further important purpose is the definition of the individual pharmacokinetics as a guide to changes of dose.
如今，测定抗癫痫药物的血清水平是癫痫治疗中最有用的辅助手段之一。对于“治疗范围”，在个别病例中最好避免提及，因为它们充其量毫无用处，而且往往会产生误导。最重要的测定是在癫痫发作后立即进行的那些，因为它们对于确定个体治疗阈值以及阐明癫痫复发原因是必不可少的。另一个重要目的是确定个体药代动力学，以此作为调整剂量的指导。
