Mikhaĭlenko A A, Dyskin D E, BNitsadze A N
Zh Nevrol Psikhiatr Im S S Korsakova. 1993;93(1):39-42.
To study clinical manifestations and pathogenetic mechanisms of long-term consequences of closed brain injury, 244 patients with a history of cerebral injury of varying severity were examined. For instrumental and laboratory verification of injury use was made of straight craniography, pneumoencephalography, computer-aided tomography, electroencephalography, rheoencephalography, psychophysiological techniques, immunological examination of the blood and CSF biochemistry. Comparative information content of the different research methods was defined. Broad clinical polymorphism and definite specificity of the manifestations of the consequences of closed braid injury of varying severity in decompensation were revealed. The role of immunological disorders (lowering of suppressor influences of T lymphocytes, elevation of the degree of autoneurosensitization) detectable in 87% of cases was established as was the importance of changes in the correlation of the main neuromediators of the CSF in the formation of the pathogenetically multilevel process of the traumatic disease of the brain.
为研究闭合性脑损伤远期后果的临床表现及发病机制，对244例有不同严重程度脑损伤病史的患者进行了检查。为对损伤进行仪器和实验室验证，采用了头颅X线平片、气脑造影、计算机断层扫描、脑电图、脑血流图、心理生理技术、血液免疫学检查及脑脊液生化检查。确定了不同研究方法的比较信息含量。揭示了不同严重程度的闭合性脑损伤失代偿期后果表现的广泛临床多态性及明确特异性。证实了87%的病例中可检测到的免疫紊乱（T淋巴细胞抑制作用降低、自身神经致敏程度升高）的作用，以及脑脊液主要神经介质相关性变化在脑创伤性疾病发病机制多层次过程形成中的重要性。
