Gaetje R, Popp L W
Department of Obstetrics and Gynecology, Christian-Albrechts-University, Hamburg, Germany.
Acta Obstet Gynecol Scand. 1994 Jul;73(6):502-7. doi: 10.3109/00016349409013440.
Differentiation of benign and malignant cystic adnexal masses by analysis of cyst fluid was investigated.
Eighty-one cystic adnexal lesions of 80 patients were punctured intraoperatively or after surgical removal. Color of the cyst fluid, cytology, concentrations of steroid hormones (estradiol, progesterone, testosterone), and tumor markers (CEA, CA 125, CA 15-3) were correlated to histology.
Color of cyst fluid was not reliable in the differential diagnosis of cystic adnexal masses. Cytology missed four out of seven malignant tumors. One mucinous cystadenoma was cytologically suspicious for malignancy. The combination of negative cytology, low tumor marker levels, and estradiol levels higher than 1000 pg/ml may support the diagnosis of a 'functional' cyst. Elevated CEA levels may be suspicious for all mucinous and malignant lesions.
Analysis of cyst fluid could not accurately discriminate between benign or malignant tumors.
研究通过分析囊液来鉴别附件囊性肿块的良恶性。
对80例患者的81个附件囊性病变进行术中穿刺或手术切除后穿刺。将囊液的颜色、细胞学、甾体激素（雌二醇、孕酮、睾酮）浓度以及肿瘤标志物（癌胚抗原、癌抗原125、癌抗原15-3）与组织学进行关联分析。
囊液颜色在附件囊性肿块的鉴别诊断中不可靠。细胞学检查漏诊了7例恶性肿瘤中的4例。1例黏液性囊腺瘤在细胞学上可疑为恶性。细胞学检查阴性、肿瘤标志物水平低且雌二醇水平高于1000 pg/ml的组合可能支持“功能性”囊肿的诊断。癌胚抗原水平升高可能提示所有黏液性和恶性病变。
囊液分析不能准确区分良性或恶性肿瘤。
