Koelliker D D, Steele P E, Hurtubise P E, Flessa H C, Sheng Y P, Swerdlow S H
Department of Pathology and Laboratory Medicine, University of Cincinnati, Ohio.
Am J Clin Pathol. 1994 Aug;102(2):212-6. doi: 10.1093/ajcp/102.2.212.
Most B-cell chronic lymphocytic leukemias and a small normal subset of B lymphocytes express the T-cell-associated CD5 antigen; expression of other T-cell antigens has been reported only rarely. The authors report two cases of typical B-cell chronic lymphocytic leukemia, seen during 1 year, in which two-color flow cytometric analysis documented expression of the T-cell-associated CD8 antigen by the monoclonal B cells. Genotypic studies showing immunoglobulin but not T-cell-receptor gene rearrangements confirmed the B-cell origin of the neoplastic cells. The true frequency of the CD8-positive B-cell chronic lymphocytic leukemia, any clinical implications, and the possibility of a normal subset of CD5-positive CD8-positive B cells remain to be determined.
大多数B细胞慢性淋巴细胞白血病以及一小部分正常B淋巴细胞亚群表达与T细胞相关的CD5抗原；其他T细胞抗原的表达仅有极少报道。作者报告了1年内见到的2例典型B细胞慢性淋巴细胞白血病，其中两色流式细胞术分析证明单克隆B细胞表达与T细胞相关的CD8抗原。基因分型研究显示免疫球蛋白而非T细胞受体基因重排，证实了肿瘤细胞的B细胞起源。CD8阳性B细胞慢性淋巴细胞白血病的真实发生率、任何临床意义以及CD5阳性CD8阳性B细胞正常亚群的可能性仍有待确定。
