Hartman K R
Department of Hematology, Walter Reed Army Institute of Research, Washington, DC 20307-5100.
Am J Med Sci. 1994 Aug;308(2):102-5. doi: 10.1097/00000441-199408000-00007.
Anti-neutrophil antibodies of the immunoglobulin G (IgG) class have been implicated in the pathogenesis of autoimmune neutropenia, but few reports have described immunoglobulin M (IgM) anti-neutrophil antibodies. To investigate the prevalence of IgM anti-neutrophil antibodies, sera from 130 patients with possible autoimmune neutropenia were studied for IgG and IgM anti-neutrophil antibodies using an immunofluorescence flow cytometric assay. Twenty-five patients (19%) had IgG anti-neutrophil antibodies exclusively, 21 patients (16%) had both IgG and IgM anti-neutrophil antibodies, and 11 patients (8%) had IgM anti-neutrophil antibodies exclusively. Immunoglobulin M anti-neutrophil antibodies were found in adults and children with isolated chronic neutropenia and in patients with Felty's syndrome, systemic lupus erythematosus, immune thrombocytopenic purpura, and human immunodeficiency virus. Patients with neutropenia with only IgM anti-neutrophil antibodies comprised almost 20% of antibody-positive patients in this study.
免疫球蛋白G（IgG）类抗中性粒细胞抗体已被认为与自身免疫性中性粒细胞减少症的发病机制有关，但很少有报告描述免疫球蛋白M（IgM）抗中性粒细胞抗体。为了研究IgM抗中性粒细胞抗体的患病率，使用免疫荧光流式细胞术检测了130例可能患有自身免疫性中性粒细胞减少症患者血清中的IgG和IgM抗中性粒细胞抗体。25例患者（19%）仅具有IgG抗中性粒细胞抗体，21例患者（16%）同时具有IgG和IgM抗中性粒细胞抗体，11例患者（8%）仅具有IgM抗中性粒细胞抗体。在患有孤立性慢性中性粒细胞减少症的成人和儿童以及患有费尔蒂综合征、系统性红斑狼疮、免疫性血小板减少性紫癜和人类免疫缺陷病毒的患者中发现了IgM抗中性粒细胞抗体。在本研究中，仅具有IgM抗中性粒细胞抗体的中性粒细胞减少症患者占抗体阳性患者的近20%。
