利什曼原虫糖体含有超氧化物歧化酶。
Leishmanial glycosomes contain superoxide dismutase.
作者信息
Dey R, Datta S C
机构信息
Indian Institute of Chemical Biology, Calcutta.
出版信息
Biochem J. 1994 Jul 15;301 ( Pt 2)(Pt 2):317-9. doi: 10.1042/bj3010317.
Abstract
In this work we report that superoxide dismutase is entrapped in a microbody-like organelle, the glycosome, present in Leishmania spp. Studies on the sensitivity of the enzyme to various inhibitors indicated that glycosomal superoxide dismutase is predominantly of the Cu/Zu type. Localization of superoxide dismutase in glycosomes points to the major importance of this organelle in the survival of this pathogen, suggesting a new approach towards chemotherapy for leishmaniasis.
摘要
在本研究中，我们报告超氧化物歧化酶被困于利什曼原虫属特有的一种类似微体的细胞器即糖体中。对该酶对各种抑制剂敏感性的研究表明，糖体超氧化物歧化酶主要为铜/锌类型。超氧化物歧化酶在糖体中的定位表明该细胞器在这种病原体的存活中至关重要，这为利什曼病的化疗提出了一种新方法。
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本文引用的文献
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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
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Biochem Biophys Res Commun. 1981 Oct 15;102(3):970-6. doi: 10.1016/0006-291x(81)91633-8.
3
A novel location for two enzymes of de novo pyrimidine biosynthesis in trypanosomes and Leishmania.锥虫和利什曼原虫中从头嘧啶生物合成的两种酶的新定位。
FEBS Lett. 1981 Jun 1;128(1):27-9. doi: 10.1016/0014-5793(81)81070-8.
4
Glycerolipid biosynthesis in peroxisomes via the acyl dihydroxyacetone phosphate pathway.通过酰基二羟基丙酮磷酸途径在过氧化物酶体中进行甘油olipid生物合成。 （注：原文中“甘油olipid”可能有误，推测应为“甘油脂质” glycerolipid ）
Ann N Y Acad Sci. 1982;386:170-82. doi: 10.1111/j.1749-6632.1982.tb21415.x.
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Metabolic pathways in peroxisomes and glyoxysomes.过氧化物酶体和乙醛酸循环体中的代谢途径。
Annu Rev Biochem. 1981;50:133-57. doi: 10.1146/annurev.bi.50.070181.001025.
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