Kahán I L, Hammer H
Arzneimittelforschung. 1975 Feb;25(2):234-7.
Tri-metacycline, one of the new tetracycline complexes (tritetracyclines), is prepared by mere dissolution of metacycline hydrochloride in an aqueous solution of the complexing agent. In vitro and in vivo studies show a high antibiotic activity. Significantly lower MIC values were found for tri-metacycline than for the parent compound. Parenteral administration resulted in high sera and tissue values, without signs of accumulation; excretion via the kidneys was proved.
