Taaning E, Jacobsen N, Morling N
Department of Clinical Immunology, State University Hospital, Rigshospitalet, Copenhagen, Denmark.
Br J Haematol. 1994 Mar;86(3):651-3. doi: 10.1111/j.1365-2141.1994.tb04801.x.
We report on a male who received a bone-marrow allograft from his HLA identical sister for acute myelogenous leukaemia. After transplantation, the patient suffered from refractoriness to the transfusions of HLA-matched platelets and a strong platelet-specific antibody, anti-HPA-2b, of IgG1 subclass was demonstrated in the patient's serum. In the serum of the bone-marrow donor a weak IgG1 anti-HPA-2b was demonstrated. IgG allotyping of the patient and donor showed identical results. We could not determine the origin of the anti-HPA-2b, although we hypothesize that the anti-HPA-2b was produced by immunocompetent donor lymphocytes infused with the suspension of bone-marrow cells.
我们报告了一名男性患者，他因急性髓性白血病接受了来自其 HLA 相同姐姐的骨髓同种异体移植。移植后，患者对 HLA 匹配的血小板输注产生抵抗，并且在患者血清中检测到一种强血小板特异性抗体，即 IgG1 亚类的抗-HPA-2b。在骨髓供者的血清中检测到弱阳性的 IgG1 抗-HPA-2b。对患者和供者的 IgG 分型显示结果相同。尽管我们推测抗-HPA-2b 是由注入骨髓细胞悬液中的具有免疫活性的供者淋巴细胞产生的，但我们无法确定抗-HPA-2b 的来源。
