Kramer E D, Vezina L G, Packer R J, Fitz C R, Zimmerman R A, Cohen M D
Neuro-Oncology Program, Cooper Hospital/University Medical Center, UMDNJ/Robert Wood Johnson Medical School, Camden.
Pediatr Neurosurg. 1994;20(4):254-62; discussion 262-3. doi: 10.1159/000120799.
Standardization of the baseline and surveillance evaluation of children with central nervous system (CNS) tumors could contribute to understanding tumor behavior, establishing prognoses, directing treatment, and interpreting multi-institutional cooperative study data. A tumor categorization schedule, based on recognized patterns of CNS tumor behavior involving 'aggressiveness' as assessed by the likelihood for neuraxis dissemination, relative time to progression and pattern of disease recurrence is presented. Included are the most common histologic subtypes of pediatric CNS neoplasms. No attempt has been made to include all histologic subtypes of pediatric CNS neoplasms. Using this categorization as a framework, recommendations are suggested for baseline evaluation at diagnosis and in surveillance.
中枢神经系统（CNS）肿瘤患儿基线和监测评估的标准化有助于了解肿瘤行为、确定预后、指导治疗以及解读多机构合作研究数据。本文提出了一种肿瘤分类方案，该方案基于中枢神经系统肿瘤行为的公认模式，包括通过神经轴扩散的可能性、相对进展时间和疾病复发模式评估的“侵袭性”。其中包括小儿中枢神经系统肿瘤最常见的组织学亚型。本文未试图涵盖小儿中枢神经系统肿瘤的所有组织学亚型。以这种分类为框架，针对诊断时的基线评估和监测提出了建议。
