[The role of invertors in the mechanism of heart function regulation].

Decrease of heart contraction function and rate, diminish of adreno- and fluoride-sensitivity of adenylate cyclase was detected under the long-time isolated rat's heart Langendorff's perfusion. Injection of rat with the Actinomycin D (an inhibitor of transcription) prevented the decline of hearts' function and adenylate cyclase activity. The addition of cytosol from cells of long-term perfused heart decreased the adrenosensitivity of adenylate cyclase of intact animal heart membranes. Actinomycin D prevented this effect. The appearance of cellular factor, which down-regulates adenylate cyclase activity (named by us an invertor) into the heart under the long-time perfusion is discussed.